The 37-year-old has asked to leave the Old Trafford club following their failure to qualify for the Champions League and is linked with a move to Chelsea.
However, he will miss the flight to Bangkok due to family issues, as confirmed by the club in a matter unrelated to his transfer future.
A statement read: “Cristiano Ronaldo will not be in the party departing for Thailand as he has been granted additional leave to sort out a family issue.”
A 31-man squad will travel to Asia for the clash with Liverpool on Tuesday ahead of friendlies against Melbourne Victory, Crystal Palace and Aston Villa.
New signing Tyrell Malacia is joined by 13 academy players on Erik ten Hag’s first tour as manager, including Alejandro Garnacho, Zidane Iqbal and Charlie Savage.
Phil Jones is out on a ‘specialised pre-season programme’, which the defender was also placed on last summer.
Also missing are Brandon Williams with a ‘little problem’ and Andreas Pereira, who recently returned from loan at Flamengo – both players are linked with moves.
Full Man United Tour squad:
David De Gea, Tom Heaton, Nathan Bishop, Matej Kovar; Eric Bailly, Diogo Dalot, Ethan Laird, Victor Lindelof, Harry Maguire, Tyrell Malacia, Luke Shaw, Alex Telles, Axel Tuanzebe, Raphaël Varane, Aaron Wan-Bissaka; Amad, Bruno Fernandes, Fred, James Garner, Hannibal, Zidane Iqbal, Scott McTominay, Facundo Pellistri, Charlie Savage, Donny van de Beek; Tahith Chong, Anthony Elanga, Alejandro Garnacho, Anthony Martial, Marcus Rashford, Jadon Sancho.